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Samsung Biologics expands into peptide manufacturing with USD 1.8b PolyPeptide acquisition

Samsung Biologics expands into peptide manufacturing with USD 1.8b PolyPeptide acquisition

Samsung Biologics (KRX: 207940) has launched an all-cash public tender offer to acquire Switzerland-based PolyPeptide Group AG (SIX: PPGN) at CHF 44.31 per share, valuing the peptide-focused contract development and manufacturing organization at approximately CHF 1.46 billion (USD 1.8 billion). The deal extends Samsung Biologics' manufacturing scope beyond antibodies and antibody-drug conjugates into peptide active pharmaceutical ingredients, positioning the South Korean CDMO to serve rising demand for GLP-1 and other metabolic disease therapeutics.

The offer represents a 40% premium to PolyPeptide's unaffected share price of CHF 31.65 as of April 10, 2026, and an 11.6% premium to the 60-day volume-weighted average. PolyPeptide's board, acting through independent members, has unanimously recommended shareholders accept the offer, and the company's largest shareholder has provided an irrevocable undertaking to tender its roughly 55.65% stake. The tender offer is expected to launch by the end of August 2026 and close by year-end. Samsung Biologics intends to pursue a squeeze-out of remaining minority shares and delist PolyPeptide from the SIX Swiss Exchange.

Peptide manufacturing has become one of the fastest-growing segments of pharmaceutical outsourcing as demand for GLP-1 receptor agonists and other peptide therapeutics has strained global production capacity. PolyPeptide operates six GMP manufacturing sites across Europe, the US and India and specializes in peptide API development and commercial manufacturing. The company operates an integrated development-to-commercial model built on modular, automated production lines. The transaction is centered on acquiring manufacturing capacity, technical expertise and a late-stage peptide project portfolio.

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The move follows a broader industry scramble to secure peptide manufacturing and formulation capacity. AstraZeneca's USD 1.2 billion upfront deal with CSPC for long-acting peptide assets reflects the same underlying demand for GLP-1 and related metabolic therapies that Samsung Biologics cites in justifying the PolyPeptide acquisition. CordenPharma's acquisition of AmbioPharm, a US- and China-based peptide CDMO, in May 2026 similarly expanded peptide API capacity in response to surging biopharma outsourcing needs, though terms were undisclosed. For Samsung Biologics, which built its business on large-molecule biologics manufacturing, the PolyPeptide deal marks a structural diversification of its CDMO platform rather than an incremental capacity add, aligning it more directly with competitors such as Lonza and CordenPharma that already offer integrated peptide services alongside biologics.


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