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Systematic, data-driven science coverage · Sunday, September 13, 2026
The AllSci BriefFree, systematic R&D and deal news. Daily.
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Development

Insilico’s rentosertib becomes first AI-discovered drug to enter Phase III

Insilico’s rentosertib becomes first AI-discovered drug to enter Phase III
Business

ViaNautis expands into spinal cord injury with SCI Ventures backing for polyNaut platform

ViaNautis expands into spinal cord injury with SCI Ventures backing for polyNaut platform
Development

Disc Medicine’s DISC-3405 reduces phlebotomy needs in Phase II polycythemia vera trial

Disc Medicine’s DISC-3405 reduces phlebotomy needs in Phase II polycythemia vera trial
Business

Insightec spinout Lotus Neuro launches brain drug delivery platform

Insightec spinout Lotus Neuro launches brain drug delivery platform
Development

AbbVie's atogepant meets primary endpoint in Phase III menstrual migraine trial

AbbVie's atogepant meets primary endpoint in Phase III menstrual migraine trial
More from Discovery
McGill and Mount Sinai researchers identify PRMT7 as suppressor of CD8+ T cell expansion
Discovery

McGill and Mount Sinai researchers identify PRMT7 as suppressor of CD8+ T cell expansion

A protein arginine methyltransferase acts as a previously unrecognized suppressor of cytotoxic T cell proliferation, offering a potential new target for...

3d agoUC Davis researchers map LSD structure to guide non-hallucinogenic drug design
Discovery

UC Davis researchers map LSD structure to guide non-hallucinogenic drug design

Researchers at the University of California, Davis have used systematic chemical deconstruction of lysergic acid diethylamide (LSD) to identify which...

3d agoGerman researchers show AI-designed protein vehicles outperform lipid nanoparticles in RNA delivery
Discovery

German researchers show AI-designed protein vehicles outperform lipid nanoparticles in RNA delivery

Researchers at Helmholtz Munich and the Technical University of Munich, led by corresponding authors Christoph Gruber, Florian Giesert, and Wolfgang Wurst,...

4d agoPeking University engineers proteins that switch on in nitric oxide-rich tissues
Discovery

Peking University engineers proteins that switch on in nitric oxide-rich tissues

A method for building proteins that activate only in the presence of nitric oxide (NO) — a signaling molecule produced at elevated levels at sites of...

Sep 4ARPA-H backs USD 125m push for distributed RNA manufacturing
Discovery

ARPA-H backs USD 125m push for distributed RNA manufacturing

The Advanced Research Projects Agency for Health (ARPA-H) has selected five teams to receive contract awards totaling up to USD 125 million under its...

Sep 3Vincere Bio wins grant for USP30 inhibitor IND-enabling studies in acute kidney injury
Discovery

Vincere Bio wins grant for USP30 inhibitor IND-enabling studies in acute kidney injury

Vincere Biosciences, a small molecule drug developer, has received a USD 1.3 million SBIR Phase II grant from the National Institute of Diabetes and...

Sep 2Boston Children's Hospital picks up USD 3.9m NIH grant to target endometriosis pain via lipid receptors
Discovery

Boston Children's Hospital picks up USD 3.9m NIH grant to target endometriosis pain via lipid receptors

Boston Children's Hospital has received a USD 3.9 million NIH R01 grant to identify specialized pro-resolving lipid mediator (SPM) receptors as druggable...

Sep 2GentiBio secures NIH backing for allogeneic engineered Treg therapy in type 1 diabetes
Discovery

GentiBio secures NIH backing for allogeneic engineered Treg therapy in type 1 diabetes

Cambridge, Massachusetts-based GentiBio, Inc. has received a USD 1.07 million NIH R44 SBIR Phase II grant from the National Institute of Diabetes and...

Sep 2
The AllSci BriefFree, systematic R&D and deal news. Daily.
Seoul team extends prime editing to large-scale DNA replacement
Discovery

Seoul team extends prime editing to large-scale DNA replacement

Researchers at Seoul National University College of Medicine have developed a prime editing-based system capable of replacing genomic sequences with DNA...

Sep 2University of Toronto, SickKids develop chemically modified tRNA platform for cystic fibrosis nonsense mutations
Discovery

University of Toronto, SickKids develop chemically modified tRNA platform for cystic fibrosis nonsense mutations

A chemically modified, lipid nanoparticle-delivered suppressor transfer RNA platform has restored functional cystic fibrosis transmembrane conductance...

Sep 2Shingrix shows potential cardiovascular benefit in US natural experiment
Discovery

Shingrix shows potential cardiovascular benefit in US natural experiment

A large observational study exploiting a natural experiment in US vaccine policy has found that recipients of the recombinant herpes zoster vaccine Shingrix...

Aug 28UC Irvine takes AI-powered metabolic imaging into drug resistance testing
Discovery

UC Irvine takes AI-powered metabolic imaging into drug resistance testing

University of California, Irvine has received a USD 3 million RC2 grant from the National Center for Advancing Translational Sciences (NCATS) to develop a...

Aug 25CDK8 emerges as potential disease-modifying target in osteoarthritis
Discovery

CDK8 emerges as potential disease-modifying target in osteoarthritis

Inhibiting a transcriptional kinase already explored in oncology can suppress the pathological cellular transition that drives cartilage breakdown in...

Aug 25Moffitt researchers identify ULK3 dependency in multiple myeloma, report preclinical inhibitor efficacy
Discovery

Moffitt researchers identify ULK3 dependency in multiple myeloma, report preclinical inhibitor efficacy

A serine/threonine kinase largely overlooked in myeloma biology drives autophagy-dependent tumor cell survival and proteasome inhibitor resistance,...

Aug 25Anthropic's Claude autonomously designs protein binders against 14 of 15 targets
Discovery

Anthropic's Claude autonomously designs protein binders against 14 of 15 targets

A large language model operating without human input into any individual design decision produced confirmed protein binders against 14 of 15 testable...

Aug 25