Discovery
UCM and MIT research shows transient CB2R modulation locks breast cancer cells into less aggressive state
A brief pulse of cannabinoid receptor 2 (CB2R) activation is sufficient to lock breast cancer cells into a less aggressive, luminal-like identity that...
Columbia-led trial reports 64% response rate in small Phase II for four-drug CXCR4 regimen
A quadruplet regimen combining the CXCR4 antagonist motixafortide (APHEXDA) with the anti-PD-1 antibody cemiplimab and standard chemotherapy produced a 64%...
NIH backs UT Southwestern push to drug STING in autoimmune disease
UT Southwestern Medical Center has received a USD 2.57 million NIH P01 Program Project grant from the National Institute of Allergy and Infectious Diseases...
Rochester Uni backed by NIH to explore PKD3 as cardiac therapeutic target
University of Rochester has received a USD 2.38 million NIH R01 grant from the National Heart, Lung, and Blood Institute (NHLBI) to investigate how protein...
Protein charge emerges as key constraint for AI-designed cancer minibinders
A study from researchers at the University of Bonn demonstrates that the isoelectric point (pI) of AI-designed protein minibinders — not just their binding...
AKR1A1 loss exposes metabolic vulnerability in drug-resistant liver, kidney cancers
Loss of a metabolic enzyme found in hepatocellular carcinoma (HCC) and renal cell carcinoma (RCC) creates a selective dependence on a detoxification pathway...
Stanford-led team engineers synthetic transcription factors to boost CAR-T cells
A combinatorial protein-engineering platform that assembles novel transcription factors from shuffled natural domains can substantially improve the...
Peking University team develops delayed STING activation strategy for mRNA cancer vaccines
A preclinical platform that chemically delays activation of the STING innate immune pathway until after antigen translation has begun produced stronger...
AI antibody design struggles to beat simple baselines in 29-organization benchmark
A prospective, blinded competition involving 29 organizations and 511 AI-designed antibody sequences has produced the most rigorous public assessment to...
University of Milan team turns senolytic drug against hard-to-treat mycobacterial infection
A senolytic drug already in clinical development for oncology can reduce bacterial burden in a notoriously treatment-resistant mycobacterial infection by...
NIH funds new blood biomarkers to track islet dysfunction in type 1 diabetes
Battelle Pacific Northwest Laboratories has received a USD 1.92 million NIH R01 grant from the National Institute of Diabetes and Digestive and Kidney...
Stanford moving novel oral influenza antiviral toward IND with NIAID backing
Stanford University has received a USD 1.27 million NIAID R56 grant to advance a novel oral small molecule antiviral against influenza A virus (IAV) toward...
Brigham wins NIA funding to test lamivudine against retrotransposons in Down syndrome Alzheimer's
Brigham and Women's Hospital has received a USD 1.47 million National Institute on Aging UG3/UH3 grant to run a two-phase clinical trial of lamivudine (3TC)...
GenBio AI unveils multiscale virtual cell model spanning DNA to phenotype
A Palo Alto-based AI company has released what it describes as a multiscale, stateful simulation of the human cell, an approach that differs architecturally...
Dana-Farber wins NCI leukemia SPORE to tackle resistance across emerging AML drug classes
Dana-Farber Cancer Institute has received a USD 2.43 million NCI Specialized Program of Research Excellence (SPORE) grant to advance translational research...
The AllSci Brief
Free, systematic R&D and deal news. Daily.