Discovery
Nanjing Medical University researchers link bacterial enzyme to improved liver cancer immunotherapy
A specific bacterium found inside liver tumors can actively organize the immune microenvironment in ways that improve responses to checkpoint blockade,...
Myeloid cell transplantation rescues Friedreich's ataxia through mitochondrial transfer in mice
Hematopoietic transplantation can rescue neurological and cardiac deficits in a mouse model of Friedreich's ataxia (FA) — not by replacing diseased neurons...
Pitt, Magee-Womens team turns cancer dormancy into a druggable vulnerability
A preclinical study from the University of Pittsburgh and Magee-Womens Research Institute & Foundation identifies a two-drug strategy that selectively kills...
Cell study uncovers polyamines as natural ferroptosis defense
Polyamines — small, positively charged metabolites long studied for roles in cell growth and translation — directly chelate labile intracellular iron and...
MGH, Harvard researchers restore PV neuron function, suppress seizures in NDD mouse model
A single transcription factor delivered to a specific class of inhibitory neurons in adult mice rescues seizures, restores hippocampal network oscillations,...
Synthetic glycan opens vaccine route against Candida auris
A single chemically synthesized sugar molecule can both vaccinate against and detect Candida auris, the multidrug-resistant fungal pathogen responsible for...
Oculogenex secures NEI grant as AMD gene therapy nears IND
Oculogenex, a La Habra, California-based gene therapy company, has received a USD 1.09 million R44 SBIR grant from the National Eye Institute (NEI) to...
Cancer's 'dark proteome' becomes new hunting ground for drug targets
Dana-Farber Cancer Institute has received a USD 1.16 million National Cancer Institute OT2 award to map and therapeutically exploit the dark proteome — a...
NCI backs Minnesota's off-the-shelf cancer-killing Treg platform
University of Minnesota has received a USD 2.08 million National Cancer Institute P01 renewal to advance off-the-shelf allogeneic immune effector cell...
Daraxonrasib study reveals resistance mechanisms in pancreatic cancer
Researchers at Redwood City, California-based Revolution Medicines and Dana-Farber Cancer Institute have published the first systematic characterization of...
Johns Hopkins probes macroH2A1 splicing as biomarker for PARP, TOP1 inhibitor response
Johns Hopkins University has received a USD 1.5 million National Cancer Institute R01 renewal to investigate how epigenetic control of single-stranded DNA...
MIT spinout Artificial Axon gets NINDS backing for MS lesion-mimicking drug screening platform
Artificial Axon Labs Inc., a Topsfield, Massachusetts-based MIT spinout, has received a USD 1.48 million SBIR R44 Phase II renewal from the National...
Velorum secures NCI grant to advance heme-targeting lung cancer therapy to IND
Velorum Therapeutics Inc., a Plano, Texas-based oncology company, has received a USD 1.26 million National Cancer Institute R44 SBIR award to advance...
Michigan team develops oral metabolite drug to boost anti-PD-1 therapy
Researchers at the University of Michigan have described what they said is the first microbial-metabolite-based oral drug designed to improve stem-like CD8+...
UPenn researchers document decade-long CD19 CAR T cell persistence in Nature Medicine
Researchers at the University of Pennsylvania's Abramson Cancer Center have documented functional persistence of anti-CD19 chimeric antigen receptor T cells...
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